Download Advances in Fertility Control and the Treatment of by G. Bettendorf (auth.), R. Rolland, R. F. Harrison, J. PDF

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By G. Bettendorf (auth.), R. Rolland, R. F. Harrison, J. Bonnar, W. Thompson (eds.)

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Read or Download Advances in Fertility Control and the Treatment of Sterility: The Proceedings of a Special Symposium held at the XIth World Congress on Fertility and Sterility, Dublin, June 1983 PDF

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35 3 Lisuride - a new drug for treatment of hyperprolactinaemic disorders R. HOROWSKI, R. DOROW, A. SCHOLZ, L. DE CECCO and W. H. F. SCHNEIDER SUMMARY Lisuride (Dopergin®), a highly active dopaminergic ergot derivative with prolactin-lowering properties, has an outstanding affinity as an agonist for dopamine receptors. It is concentrated by a factor of 5-10 above lisuride plasma levels within the pituitary where it acts on dopamine receptors which inhibit prolactin release. In rats, oral lisuride is 10-30 times more active on a weight basis as a prolactinlowering agent than bromocriptine.

B is the sum of the scores for the last 10 days (rebound). 2 0 0 0 10 0 0 4 0 0 2 0 0 2 0 0 0 0 0 0 Secretion B** A* Lisuride Overall clinical evaluation of effects of bromocriptine and lisuride on sulpiride-induced hyperproladinaemia t 1 3 4 5 7 8 10 11 12 15 18 19 22 23 26 28 29 31 33 37 38 Patient No. Table 4 14 0 6 0 0 0 0 3 0 0 0 0 0 0 4 1 0 0 0 B t:) t"" 0 :;:1 o-l >< n 0 Z o-l ...... t"" ...... j >tj Z ...... j ):- <: ):- ADVANCES IN FERTILITY CONTROL According to its direct effect on the prolactin-producing cell, lisuride can lower prolactin levels in all situations, and thereby change or restore biological function.

The recently introduced triphasic formula with 40% less levonorgestrel as compared with sub-50 oral contraceptives containing this progestogen does not have this disadvantage: despite the low dose of progestogens its cycle control and overall tolerance are excellent!. In 1981 Marvelon was introduced. This sub-50 oral contraceptive contains desogestrel - a new progestogen, which has been claimed to be a more specific progestogen than levonorgestrel with less androgenic residual effects 2 • From the data presented so far it can be questioned whether these findings, often based on receptor studies, have any significant clinical relevance.

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