Download Ageing: Lessons from C. elegans by Anders Olsen, Matthew S. Gill PDF

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By Anders Olsen, Matthew S. Gill

This e-book brings jointly in a single quantity the present country of ageing learn within the nematode Caenorhabditis elegans. The authors are best researchers within the box, putting this subject within the context of human getting old, describing how and why easy discoveries during this basic organism have impacted our clients for intervention within the getting old technique. The authors conceal a large variety of issues just about organismal and reproductive getting old together with anatomical, physiological and biochemical adjustments, in addition to genetic and environmental interventions that advertise sturdiness and ameliorate age-related ailment. growing old is the only most vital issue deciding on the onset of human sickness in built international locations. With present around the world demographic traits indicating that the variety of members over the age of sixty five will proceed to upward thrust, it's transparent that an realizing of the methods that underpin growing older and age-related ailment represents a key problem within the biomedical sciences. lately there were large advances in our figuring out of the aging strategy and plenty of of those have stemmed from genetic research of C. elegans.

With no analogous publication during this topic quarter this paintings may be of curiosity to a large viewers, starting from educational researchers to the final public.

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Extra resources for Ageing: Lessons from C. elegans

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1371/journal. 0030025 19. Johnson TE, Wood WB (1982) Genetic analysis of life-span in C. elegans. Johnson TE (1987) Aging can be genetically dissected into component processes using long-­ lived lines of C. elegans. Proc Natl Acad Sci USA 84(11):3777–3781 21. Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Genetic analysis of tissue aging in C. elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161(3):1101–1112 22. Page AP, Johnstone IL (2007) The cuticle.

All cilia and dendritic segments in the 15-day animal are more electron dense than in the young adult, and the AFD villi appear to have shrunken in diameter (Image source: [Hall] b SW8; c N813 537). Bar, 1 μm sometimes accumulates vacuoles and small dark endosomes. As individual glial cells shrink, the narrow extracellular channel around the cilia can become progressively wider, but the opening to the exterior environment remains patent, and even very old cilia are likely to remain exposed to environmental signals.

Elegans. Science 216(4549):1012–1014 36. Toth ML, Melentijevic I, Shah L, Bhatia A, Lu K, Talwar A, Naji H, Ibanez-Ventoso C, Ghose P, Jevince A, Xue J, Herndon LA, Bhanot G, Rongo C, Hall DH, Driscoll M (2012) Neurite sprouting and synapse deterioration in the aging C. elegans nervous system. J Neurosci 32(26):8778–8790. 2012 37. Chew YL, Fan X, Gotz J, Nicholas HR (2013) PTL-1 regulates neuronal integrity and lifespan in C. elegans. J Cell Sci 126(Pt 9):2079–2091. Pan CL, Peng CY, Chen CH, McIntire S (2011) Genetic analysis of age-dependent defects of the C.

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