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By Frederick F. Holmes M.D. (auth.)

The lifetime of a individual is finite, and all people age (see Fries 1980). it's tricky to split the consequences of sickness on organs and tissues from these anticipated of getting older. this is often rather precise for vascular and degenerative methods, for which there aren't any transparent barriers among getting older and illness. Morbidity and mortality from center sickness and stroke are most likely due either to disorder and to alterations of getting older. For melanoma, the second one major explanation for demise in the US, the location is kind of various; melanoma is obviously a sickness and isn't a transformation anticipated with getting older. melanoma occurrence raises virtually logarithmically after age forty. within the usa approximately one-half of all circumstances of melanoma are clinically determined after age sixty five, even supposing these over sixty five contain below one-eighth of the inhabitants. hence, melanoma is especially a lot a disorder of the aged. There are not less than purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning energy of immune defenses opposed to cancer.

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1 shows that incidence slowly rises from the fifties to the eighties, the increase being eightfold between the extremes of ages 50 and 85+. In spite of much conjecture about the possible causes of leukemia, only exposure to significant amounts of radiation and a few chemicals, notably benzene compounds, is known to predispose to this disease, though some familial factors may be of importance (Jablon 1975; Infante et al. 1977). Years spent searching for a viral cause have been largely unrewarded, at least for leukemia in humans (Murphyet al.

Lancet 1: 248-250 Miller TP, Jones SE (1979) Chemotherapy of localized histiocytic lymphoma. Lancet 1: 358-360 Portlock CS, Rosenberg SA (1979) No initial therapy for stage III and IV non-Hodgkin's lymphomas of favorable histologic types. Ann Intern Med 90: 10-13 Rigby PG, Pratt PT, Rosenlof RC, Lemon HM (1968) Genetic relationships in familial leukemia and lymphoma. Arch Intern Med 121: 67 -70 Schein PS, DeVita VT, Hubbard S, Chabner BA, Canellos GP, Berard C, Young RC (1967) Bleomycin, adriamycin, cyclophosphamide, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma.

Portlock and Rosenberg (1979) have made a good case for delaying treatment in this fairly common clinical situation. 60). These data have special relevance fot the elderly, who may not always be good candidates for aggressive chemotherapy. Obviously, great care should be taken in selecting the correct treatment or in delaying treatment for the older patient. Because stage has less meaning in lymphoma the survival data are presented here in the aggregate, with no attempt to consider the stage at diagnosis.

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